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Systemic inflammation indices generated from first-trimester blood tests can be potential biomarkers for predicting preeclampsia
Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality, affecting 3 to 8% of pregnancies. Currently, no clinically useful predictive biomarker exists. Preeclampsia is characterised by systemic inflammatory responses that may be triggered by placental materials released into the maternal circulation, leading to an overly active maternal immune system...
Next-generation therapies for osteoarthritis: the evolving role of cell therapy products
Osteoarthritis (OA) remains a major cause of disability worldwide; however, current non-surgical treatments offer transient symptom relief without altering disease course. This leaves a therapeutic gap for patients with early-to-moderate disease who are not candidates for surgery but continue to experience pain and functional limitation. Intra-articular interventions such as non...
Pediatric Melanoma: Emerging Therapies and Ongoing Clinical Trials
Pediatric melanoma is a rare but clinically distinct malignancy, accounting for 1–4% of all melanoma cases. It encompasses unique subtypes—Spitzoid melanoma, melanoma arising in congenital melanocytic nevi, and conventional melanoma—each with specific biological behavior and therapeutic implications. While surgical excision remains the primary treatment, systemic therapies are...
Perceived barriers and facilitators to nursing process usage: a narrative review
Background The nursing process (NP) is a systematic, patient-centred framework fundamental to professional nursing practice, yet its implementation remains suboptimal, particularly in low- and middle-income countries (LMICs). This narrative review examines the global implementation of the NP, with a focused case analysis of evidence from Pakistan (n = 2 studies) and other LMICs...
Assessment of surface roughness, dimensional accuracy, and hardness in 17-4PH stainless steel standardized artifacts manufactured by atomic diffusion additive manufacturing
Additive manufacturing offers significant advantages over conventional technologies and continues to expand in the industrial sector through the incorporation of metallic materials. However, certain aspects, such as surface finish and dimensional accuracy, still lag behind those achieved by CNC subtractive technologies. Several technologies, including material extrusion (MEX) and...
Decriminalizing same-sex relationships and its impact on social media discussions in Asia
While legal reforms may coincide with shifts in public discourse, broader normative change often remains uneven and context dependent. Since 2018, four Asian countries—India, Taiwan, Thailand and Singapore—have decriminalized same-sex relationships, providing an opportunity to examine how such institutional changes are associated with public discussions of LGBTQ+ topics. Here...
Snapshot 3D image projection using a diffractive decoder
3D image display is essential for next-generation volumetric imaging; however, dense depth multiplexing for 3D image projection remains challenging because diffraction-induced cross-talk rapidly increases as the axial image planes get closer. Here, we introduce a 3D display system comprising a digital encoder and a diffractive decoder, which simultaneously projects different...
MEMS vapor cells-based Rydberg-atom electrometry toward miniaturization and high sensitivity
Rydberg-atom electrometry, as an emerging cutting-edge technology, features high sensitivity, broad bandwidth, calibration-free operation, and beyond. However, until now the key atomic vapor cells used for confining electric field-sensitive Rydberg atoms nearly made with traditional glass-blown techniques, hindering the miniaturization, integration, and batch manufacturing. Here...
Synthesis of bundle copolymers as an emergent class of copolymer architecture
Copolymers play a central role in soft materials owing to their capacity for diverse molecular designs. While numerous combinations of composition and topology have been explored for the development of copolymers, only four types of basic architecture (random, sequence-controlled, block, and graft) have been synthetically and historically achievable. Herein, we introduce an...
Global invertibility of Sobolev mappings with prescribed homeomorphic boundary values
Let \(X, Y \subset \mathbb {R}^n\) be Lipschitz domains, and suppose there is a homeomorphism \(\varphi :\overline{X} \rightarrow \overline{Y}\). We consider the class of Sobolev mappings \(f \in W^{1,n} (X, \mathbb {R}^n)\) with a strictly positive Jacobian determinant almost everywhere, whose Sobolev trace coincides with \(\varphi \) on \(\partial X\). We prove that every...
Human–AI collaboration for dysphagia rehabilitation from effectiveness to implementation complexity: a systematic review
Oropharyngeal dysphagia affects over half of neurological and oncological populations, yet rehabilitation is constrained by a global therapist shortage that human–AI collaboration has not demonstrably addressed. Here we report a systematic review of 31 studies (1012 participants; PROSPERO: CRD420251115997) evaluating AI-augmented swallowing rehabilitation in adults with...
Efficient multiscale design of microstructure evolution in shape rolling: a validated FEM-FCA framework
Accurate prediction and design of microstructure evolution are essential for optimizing the mechanical performance of shape-rolled components. This work presents an efficient multiscale FEM–FCA computational framework that enables proactive microstructure design in shape rolling processes. The framework integrates Finite Element Method (FEM)-derived thermomechanical fields with a...
Nephroureterectomy for upper tract urothelial carcinoma recurrence in bladder cancer patients treated with radical cystectomy: a multicentric propensity score matched analysis on predictors, practice patterns and survival outcomes
Aim (I) To determine clinicopathological determinants of metachronous Upper Tract Urothelial Carcinoma (UTUC) requiring Radical Nephroureterectomy (RNU) after Radical Cystectomy (RC). (II) To evaluate long-term survival of patients who underwent RC + RNU compared with matched RC only controls. Methods Patients undergoing RNU for metachronous UTUC were extracted from a multi...
Artificial intelligence literacy and influencing factors among clinical nurses in southeastern China: a latent profile analysis
Background The rapid integration of artificial intelligence (AI) in clinical settings presents unprecedented opportunities, yet it concurrently triggers significant challenges, including ethical dilemmas, technology-induced anxiety, and care quality. Although clinical nurses are the primary users of healthcare AI, their literacy levels and cognitive profiles remain largely...
A configurational perspective of marketing’s role in the performance of tech-based ventures
While existing research has examined how founders’ marketing experience and the presence of a Chief Marketing Officer relate to the performance of tech-based ventures, we broaden this perspective by studying how these roles may be complemented or substituted by early marketing managers and marketing employees. Relying on a configurational approach, we acknowledge that multiple...
Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis
T cells are central drivers of inflammation across autoimmune and inflammatory diseases, yet current therapies inadequately target pathogenic T-cell pathways, limiting durable disease control. Here, we identified a novel, targetable transcriptional-metabolic axis that sustains inflammatory T-cell responses, characterized by NFATc1-regulated activation of MTHFD2-dependent one...
Comparative impact of clear aligners versus fixed orthodontic appliances on periodontal health, pain, and quality of life: a systematic review and meta-analysis
ObjectiveClear aligners have become a popular alternative to fixed appliances because they offer esthetic advantages and potential improvements in periodontal health and pain management while enhancing quality of life (QOL). This systematic review and meta-analysis investigated the effects of clear aligners versus fixed appliances on established outcomes.Materials and methodsA...
Diffusion-based valuable NFT generation
Non-fungible tokens (NFTs) have revolutionized digital ownership, offering unique provenance and value to digital assets. Existing text-to-image models do not have the incentive mechanisms to generate statistically rare features, even when they optimize for visual fidelity. This paper introduces DiffNFTGen, a new generative framework that is the first to combine a customized...
Cerebrovascular vulnerability and fibrosis in human brain aneurysms
Brain aneurysms are a cerebrovascular disease that results in a severe type of stroke. The cell-specific molecular pathology underlying their formation and rupture is unknown. Here we profile 227,663 neurovascular cells, including 52,946 aneurysmal cells, from a total of 14 adult human brain aneurysms and 11 control vessels. Our atlas of human brain aneurysms, as well as cell...
S100A10-ANXA2 tetramer inhibition hampers hepatic stellate cell activation in human MASLD organoids
Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD), initiated by the pathological lipid accumulation within hepatocytes, can progress towards Metabolic dysfunction-Associated SteatoHepatitis (MASH) characterized by inflammation and fibrosis. Hepatic fibrosis is the strongest predictor of liver-related mortality, yet effective antifibrotic therapies remain limited...
Loss of systemic anti-viral immunity and LMP1-driven suppressive myeloid tumour niches converge to shape the immunobiology of Epstein-Barr virus-positive diffuse large B-cell lymphoma
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (EBV⁺DLBCL) is an aggressive lymphoma with poor outcomes and an incompletely understood pathogenesis, frequently attributed to immunosenescence. However, its occurrence across all age groups suggests alternative mechanisms. Here, we integrate functional profiling of peripheral antiviral T-cell immunity with high...
Micro-TESE in men with non-obstructive azoospermia: a narrative review of sperm retrieval benefit, testicular injury, and endocrine risk
Background Microdissection testicular sperm extraction (micro-TESE) is an important treatment option for men with non-obstructive azoospermia (NOA) because it can provide sperm for intracytoplasmic sperm injection when other routes to biological fatherhood are unavailable. Counseling, however, should include not only the probability of sperm retrieval but also postoperative...
From Lived Experience to the Policy Table: Reimagining Child Welfare Through Peer Recovery Specialists
Parental substance use is a central driver of child welfare system involvement in the United States, yet child welfare policy often operates in tension with recovery-oriented approaches to substance use. This commentary argues that integrating lived experience into child welfare policymaking is both an ethical imperative and a pragmatic strategy for improving policy alignment...
Strain-rate-dependent compressive behaviour and constitutive modelling of circular WAAM ER70S-6 steel walls
Circular collars and wall-type components fabricated using wire-arc additive manufacturing (WAAM) are increasingly being considered for load-bearing steel applications. However, detailed compressive properties and constitutive models are limited. In this study, a circular ER70S-6 steel wall of five layers deposited on the SS400 substrate by WAAM was explored to understand the...
THE EFFECT OF CAPITAL EXPENDITURE ON RETURN ON EQUITY: DUPONT APPROACH ANALYSIS
This study examines the effect of CapEx on ROE using the DuPont Analysis framework and investigates the mediating roles of NPM, TAT and EM in this relationship. The study employs a quantitative approach using panel data from seven companies over the 2020-2024 period, yielding 35 observations. Data are analyzed using panel data regression with Fixed Effect and Random Effect Models...
Determinants of workplace violence against nurses and mitigation strategies in hospitals in developing countries: a scoping review
Background Violence against nurses has become a serious concern, especially in developing countries. Given the critical role that nurses play in healthcare, it is essential to implement interventions aimed at reducing this violence. The objective of this study was to identify the causes of violence against nurses in hospitals in developing countries and to propose mitigation...