Author Correction: A mechanical ratchet drives unilateral cytokinesis

Publisher Correction: Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome

The Role of Multicultural Islamic Education in Building National Unity Towards a Golden Indonesia in 2045: Peran Pendidikan Islam Multikultural dalam Membangun Persatuan Nasional Menuju Indonesia Emas 2045

General Background: Indonesia’s multicultural reality, characterized by diverse ethnic, religious, linguistic, and cultural identities, represents both a national asset and a challenge for sustaining social cohesion. Specific Background: Increasing intolerance, discrimination, and socio-cultural disparities indicate that diversity has not been fully optimized as a foundation for...

Correlation Between Best Speaker Program Perception and Arabic Speaking Confidence of Naatiq International Arabiyyah Alumni

This study aims to determine the relationship between the perception of Naatiq course alums of the Best Speaker program and their level of confidence in speaking Arabic at the Naatiq International Arabiyyah program. This research uses a quantitative, correlational design. The study population consisted of Naatiq course alumni from a single program period at Naatiq International...

Evolutionary characterization of lung cancer metastasis

Limited understanding of the biological processes that govern metastatic dissemination hinders its prevention and treatment1. Here, using 501 longitudinally collected primary and metastatic tumour samples from 24 patients with non-small cell lung cancer (NSCLC) enrolled in the TRACERx lung study and PEACE autopsy programme, we infer tumour evolution from diagnosis to death. With...

Postprandial lipid metabolism durably enhances T cell immunity

Although intrinsic metabolic pathways have critical roles in T cell function1,2, systemic nutrient availability is in constant flux. Yet, how postprandial metabolism affects T cell fate has been less studied. Here we show that the short-term nutritional state of an individual has marked effects on T cell immunity. Human or murine T cells from fed hosts had higher metabolic...

Submicrometre sampling of living cells by macrophages

An effective immune system must sample and develop healthy self-identity to prevent autoimmunity and to discern pathogenic insults1,2,3. Self-proteins are presented to T cells in the thymus during immune cell development2,3 and must be presented throughout the body to maintain regulatory T cell populations4,5,6 and to provide tonic signals to sustain conventional T cells over...

Composable neural emulators accelerate thermoelectric generator design

Designing high-performance thermoelectric (TE) devices is challenging because it requires not only advanced materials but also optimal configurations, which are critical for maximizing device performance but remain time-consuming and resource-intensive to identify1,2,3,4,5. Here we develop TEGNet, a neural network emulator that predicts TE generator performance with greater than...

Correlation between Interactive Multimedia-Based Suggestopedia and Vocabulary Mastery of Beginner Arabic Learners

This study aims to analyze the relationship between the application of the Suggestopedia method based on interactive multimedia and vocabulary mastery (mufradat) among beginner Arabic language learners. This research uses a quantitative, correlational design. The research population consists of 10th-grade students at MAN 3 Banyuwangi for the 2025/2026 academic year, with a sample...

EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk

Epstein–Barr virus (EBV) infects more than 95% of adults worldwide but is associated with endemic nasopharyngeal carcinoma (NPC) specifically in southern China1,2,3,4. Here, through a stepwise host–EBV genome interaction analysis, we identify a genetic interaction between HLA-A*11:01 and the high-risk EBV variant 85841G as a key determinant of NPC risk. Individuals carrying a...

Cultural Performance and Religious Nationalism: A Theoretical Model of Value Internalization through Wayang Aji Narantaka

This study examines the role of Wayang Kulit, particularly the Aji Narantaka episode, as a medium for the internalization of religious nationalism within rural communities. The study focuses on a community service program conducted in Temengeng Village, Blora Regency, where wayang performances had been absent for more than a decade despite previously functioning as an important...

Machine learning prediction of dual absorber lead-free perovskite solar cells for boosting PCE

Curtailing the toxicity level of perovskites is a considerable obstacle resisting the wide-scale commercialization of perovskite solar cells (PSCs). This study investigates the impact of implementing several charge transport layers (CTLs) on the performance of the proposed lead-free Cs2TiCl6/ Cs2AgBiI6 PSC employing SCAPS-1D simulations. Additionally, the effect of variations in...

PROMOSI KESEHATAN TENTANG KEBERSIHAN REPRODUKSI PADA WANITA USIA SUBUR DI PINGGIRAN SUNGAI MARTAPURA

Kebersihan reproduksi menjadi salah satu hal penting dalam pencegahan masalah kesehatan reproduksi, berupa infeksi saluran kemih (ISK) dan keputihan yang sering dialami oleh wanita usia subur. Wanita usia subur yang tinggal di pinggiran sungai lebih berpotensi karena adanya keterbatasan sanitasi dan kurangnya informasi. Kurangnya edukasi terkait kesehatan reproduksi karena...

A large Chinese dataset of ten-category semantic relations with developmental performance in children and adolescents

Semantic relations are fundamental to human conceptual knowledge and underpin cognitive processes such as categorization, analogical reasoning, and language comprehension. Despite extensive research on semantic relations in English, a systematic Chinese dataset aligned with established taxonomies remains unavailable, limiting cross-linguistic and developmental research. Here, we...

The brain-lung immunotherapy prognostic (BLIP) Score: a novel robust tool for prognostication in non-small cell lung cancer patients with brain metastases

BackgroundLung cancer is the leading cause of cancer-related mortality, with brain metastases (BMs) significantly worsening prognosis. While Immune checkpoint inhibitors (ICIs) have transformed treatment for non-small cell lung cancer (NSCLC), robust prognostic tools are still lacking.MethodsThe Brain-Lung Immunotherapy Prognostic (BLIP) score was developed using a retrospective...

Resting-state functional connectivity of the default mode network as a predictor for escitalopram response in adolescents with depression

Adolescent depression differs from adult depression in neurobiology and treatment response. Although resting-state functional connectivity (rsFC) of the default mode network (DMN) has been linked to treatment response in adults, its value as a biomarker in adolescents remains unclear. This study investigated whether baseline DMN rsFC predicts response to selective serotonin...

Validation of digital anthropometric measurements during pregnancy: a longitudinal study

Background/ObjectivesMaternal anthropometric changes are rapid during pregnancy and reflect increments in maternal and fetal tissues. These dynamic changes in body composition and shape during pregnancy are associated with maternal and fetal outcomes and are often monitored with simple tools such as a flexible tape for quantifying selected circumferences. The current study aim...

IMPLEMENTASI MANAJEMEN RISIKO PENGOBATAN ANTIHIPERTENSI DENGAN PENDEKATAN APLIKASI TENSICARE BERBASIS SMARTPHONE

Penyakit Tidak Menular merupakan penyebab utama angka kematian global 43 juta jiwa pada kasus tahun 2021, terutama akibat penyakit kardiovaskular. Survei Kesehatan Indonesia (SKI) 2023 melaporkan prevalensi hipertensi sebesar 30,8% pada usia ≥ 18 tahun, mencapai sekitar 60,8 juta penderita. Hasil Pengabdian kepada Masyarakat (PkM) tahun 2024 pada warga RW 03 Kelurahan Binong...

A multicenter study on occult lymph node metastases in sinonasal malignancies

Surgical interventions for head and neck carcinoma patients with clinically node-negative neck encompass either elective neck dissection (ND) during primary tumor excision or a wait-and-scan approach. For the rare entity of sinonasal malignancies, no standard guideline exists. This study aims to assess the prevalence of occult lymph node metastasis and evaluate the impact of...

Differential effects of prior versus concomitant Steroid and Antibiotic Treatment on Immunotherapy Efficacy - A Pooled Analysis of the RAMONA, INTEGA, OPTIM, ELDORANDO, FORCE, TITAN-RCC and TITAN-TCC Trials of the German AIO Study Group

BackgroundWe explored the association of immune-related adverse events (irAE), along with prior and concomitant antibiotic and steroid use, on oncological outcomes following immune checkpoint inhibitor (ICI) treatment in various solid tumours.MethodsPooled data from seven trials on ICI therapy across multiple cancer types (head and neck, non-small cell lung cancer...

Nutritional state-dependent changes in subcortical limbic structures in anorexia nervosa are linked to leptin, ghrelin, and neurofilament light

Anorexia nervosa (AN) involves limbic dysfunction, yet its neurobiology remains unclear. Examining morphological alterations in subcortical limbic regions across AN’s nutritional states and associations with neuroendocrine markers may improve understanding. We hypothesized that subcortical limbic volumes would be reduced in AN, normalize partially following short-term weight...

The Effect of Trust, Income, and Life Style on Fashion Purchase Decisions Using Paylater Among Accounting Students at UPN “Veteran” East Java

This study aims to examine and analyze the effect of trust, income, and life style on fashion purchase decisions using paylater among Accounting students at UPN “Veteran” East Java. The background of this research is based on the rapid development of financial technology and e-commerce, which has influenced consumer behavior, particularly among university students, including...

Clinico-molecular predictors of durable response to immune checkpoint inhibitors (ICI) in metastatic cervical cancer (mCC)

BackgroundImmune checkpoint inhibitors (ICI) are approved for metastatic cervical cancer (mCC) after platinum failure, but only a minority of patients derive durable benefit. We aimed to compare long-term responders (LTR) and non–long-term responders (NLTR) to ICI and to identify clinical and molecular predictors of long-term response.MethodsWe retrospectively reviewed patients...

PENGUATAN PERAN AKTIF MASYARAKAT BERBASIS BUDAYA UNTUK MEWUJUDKAN DESA SEHAT DAN BAHAGIA

Tantangan yang dihadapi di wilayah masyarakat Banjar antara lain ketimpangan akses layanan kesehatan, kurangnya edukasi kesehatan berbasis budaya, serta perubahan gaya hidup. Di tengah tantangan tersebut, pendekatan partisipatif berbasis kearifan lokal suku Banjar menjadi sangat relevan untuk dikembangkan demi terwujudnya Desa Sehat dan Bahagia. Hasil kajian di wilayah kerja...

Carprofen and buprenorphine delivery using micropipette-guided drug administration (MDA) in mice

Refined, non-invasive analgesic delivery methods are essential for improving animal welfare and ethical standards in laboratory rodent research. Here, we evaluated whether the micropipette-guided drug administration (MDA) method, which promotes voluntary consumption using a sweetened condensed milk vehicle, achieves therapeutically relevant plasma and brain concentrations of two...

Exact wave structures in magneto-optic soliton channels governed by Kudryashov-type coupled Schrödinger dynamics

This research establishes a comprehensive theoretical framework for soliton propagation in magneto-optic waveguides by investigating a generalized coupled Kudryashov-type nonlinear Schrödinger system under the influence of higher-order nonlinear effects. The primary objective is to resolve the complex interplay between self-steepening, nonlinear dispersion, and magnetization...

Uniaxial structural flexibility of an anisotropic Br adlayer structure on Au(100) electrodes revealed by video-rate STM

The motion of surface species within a dense layer of coadsorbates, a common case in real-world interface systems, relies on structural flexibility of the coadsorbate phase. Here, we study by video-rate scanning tunneling microscopy the lateral deformability of the pseudo-hexagonal \(c(\sqrt{2}\times 2\sqrt{2})R4{5}^{\circ }\)-Br adlayer on Au(100). It is shown that the...

Circulating tumour cell-derived xenograft as a preclinical platform for metastatic breast cancer

BackgroundCirculating tumour cells (CTCs) are mediators of cancer dissemination and the formation of metastasis, which is the leading cause of cancer-related deaths. Experimental models derived from CTCs contribute to understanding the biology of CTCs, their role in dissemination, and the discovery of potential drugs targeting CTCs.MethodsA xenograft was derived from CTCs...

Adjunctive D-cycloserine to intermittent theta-burst transcranial magnetic stimulation in fibromyalgia: a randomized placebo-controlled trial

Fibromyalgia is a chronic condition with a substantial unmet treatment need. Repetitive Transcranial Magnetic Stimulation (rTMS) has shown promise in decreasing fibromyalgia symptom severity. Emerging data suggest that adjunctive administration of the N-methyl-D-aspartate receptor partial agonist, D-Cycloserine, with rTMS can significantly improve clinical outcomes for other rTMS...

ARUTMIN’S CSR FOOTPRINT IN THE SDGS: PROMOTING INCLUSIVE HEALTH IN THE KINTAP MINING AREA

Responsibility (CSR) initiatives, such as maternal and child health check-ups, elderly health services, youth education, and HIV/AIDS awareness campaigns. These community service activities aim to improve public health quality in the mining area through participatory and collaborative approaches. The implementation process begins with assessing community needs through interviews...