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Assessment of Biology Laboratory Management and Facilities in Public Senior High Schools

Biology laboratories play an important role in supporting practical learning activities and developing students’ scientific skills in science education. Effective laboratory management and adequate facilities are necessary to ensure that practical activities are conducted safely and optimally. This study aimed to analyse: (1) the management of biology laboratories, (2) the...

Angular spectrum-encoded single-shot ultrafast photography

Capturing transient events on ultrafast time scales demands imaging at up to trillions of frames per second (Tfps). Yet leading methods, including compressed sensing-based photography, time-resolved shadowgraphy, and other active approaches, are limited by bulky optics, high cost, and repeated measurements. Here, we propose angular spectrum-encoded single-shot ultrafast...

Oral small molecule GLP-1 receptor agonist aleniglipron in people with overweight or obesity: a randomized, double-blind, placebo-controlled phase 2b trial

Aleniglipron is an oral, small-molecule glucagon-like peptide-1 receptor agonist (GLP1-RA) in development for obesity treatment. The ACCESS phase 2b placebo-controlled, double-blind study randomized 230 adults (mean BMI 39.5 kg m−2, 54% female) with obesity or overweight to examine the effects of once-daily aleniglipron escalated every 4 weeks to 45, 90 or 120 mg. At week 36, the...

Anti-Tuberculosis Drug Resistance Patterns In Patients With Pulmonary Tuberculosis

Background: In 2022, Indonesia reported a pulmonary tuberculosis (PTB) incidence rate of 354 per 100,000 population, with an estimated 24,666 cases of drug-resistant pulmonary tuberculosis (DR-TB). Nationally, DR-TB case detection coverage reached 50.8%, with 12,531 patients notified—an increase of 17% from the previous year. Method: This study aimed to examine patterns of Anti...

EFEKTIVITAS PENEGAKAN HUKUM DALAM MENJAGA KETERTIBAN SOSIAL: STUDI EMPIRIS KASUS PENGEROYOKAN PEMUDA DI SUMBA BARAT DAYA

Penelitian ini bertujuan untuk mengkaji secara mendalam peran penegak hukum dalam mewujudkan ketertiban sosial melalui analisis kasus pengeroyokan terhadap dua pemuda di Kabupaten Sumba Barat Daya, Nusa Tenggara Timur. Peristiwa tindak kekerasan yang dilakukan secara bersama-sama terhadap Rafael Ngara Kii dan Daniel Toda Baru mengakibatkan keduanya luka berat, serta diproses...

Intelligent label-free droplet microfluidic sorting system for single-cell encapsulation and morphology-guided screening

The label-free extraction of cellular morphological data from within droplet microenvironments, and its subsequent translation into reliable, high-precision sorting, continues to pose a central challenge in the field of droplet microfluidics. Here, we develop an intelligent label-free droplet sorting (ILFDS) system by integrating droplet microfluidics, real-time image recognition...

On the origin of acoustic emission in the stress-induced martensite regime of shape memory alloys

The superelastic (SE) deformation behavior of Heusler-type Co-Ni-Ga shape memory alloy (SMA) single crystals is investigated employing complementary in situ techniques. Findings obtained by optical microscopy, neutron diffraction and acoustic emission (AE) provide deep insights into the microstructural events taking place during compressive loading. In addition to the martensitic...

DN203316, a novel PPARδ agonist, suppresses ferroptotic signaling and fibrogenesis in metabolic dysfunction-associated steatohepatitis

Recently, ferroptosis has emerged as a pathogenic mechanism that drives metabolic dysfunction-associated steatohepatitis (MASH); however, the upstream triggers and their relevance to fibrosis remain poorly understood. Here we identified dietary cholesterol-induced ferroptosis and the downregulation of peroxisome proliferator-activated receptor delta (PPARδ) as central drivers of...

Tabi‘in Perempuan dalam Periwayatan Hadis: Analisis Konten dan Otoritas Sanad dalam Musnad Ahmad bin Hanbal.

This study examines the role of tabi’iyyat generation in the transmission of hadith in the Musnad of Ahmad ibn Hanbal. Through a qualitative literature review, primary data was analyzed using Krippendorff’s content analysis model and Mahmud al-Thahhan’s sanad analysis. The macro level findings successfully identified a data population of 126 tabi’iyyat. Thematically, the content...

The protective effect of cutaneous vagus nerve stimulation from necrotizing enterocolitis (NEC) in neonatal rats

BackgroundNecrotizing enterocolitis (NEC) is a major source of morbidity and mortality among premature infants. Vagus nerve stimulation (VNS) has proven anti-inflammatory effects. Animal studies indicate that vagus nerve activity may dampen NEC inflammation.MethodsWe used an animal model that induces NEC in rat pups. Newborn pups were divided into six treatment groups: Pups...

Correlation between Grit score, academic achievement and learning approaches of dental students

BackgroundImportance of non-cognitive skills such as Grit is being increasingly recognised. Grit is the perseverance and passion needed to achieve long-term goals in the face of challenges. This study examines the relationship between Grit scores, academic achievement and learning approaches of dental studentsMethodsIn this mixed method study, a validated Short Grit Scale was...

An active Helitron transposon family in wheat

Transposable elements play a pivotal role in genome evolution and phenotypic variation in numerous eukaryotic species1. Helitrons, a recently identified category of transposons, remain poorly understood in terms of epigenetic regulation and real-time mobilization in plants2,3. Here our study reveals that reduced DNA methylation combined with heat stress promotes the mobilization...

The European Upper Palaeolithic Palaeoecological and Archaeological Dataset for sites north of 50°N

The European Upper Palaeolithic Palaeoecological and Archaeological Dataset for sites north of 50°N (EUPPAD) presents a systematic collection of palaeoecological and archaeological data from Upper Palaeolithic sites across Europe north of 50°N. Spanning c. 47,000–14,000 cal BP, this dataset integrates site, lithic assemblages, faunal, floral, and contextual records to support...

A fixed methane filter maximizes freshwater emissions under warming

Approximately half of all methane (CH4) emissions come from freshwaters, where they are regulated by the microbial ‘CH4 filter’ whose efficiency describes the fraction of CH4 produced that is subsequently oxidized back to CO2 (methanotrophy) before emission. How the CH4 filter efficiency responds to natural warming over centuries or millennia remains unknown. Here we address this...

HUBUNGAN INDEKS MASA TUBUH DENGAN INTENSITAS NYERI HAID PADA REMAJA PUTERI DI KOTA PALEMBANG

Nyeri menstruasi atau dismenore merupakan salah satu masalah kesehatan reproduksi yang paling sering dialami oleh wanita. Dismenore dapat mengganggu aktivitas sehari-hari, prestasi akademik, dan kualitas hidup. Salah satu faktor yang diduga berhubungan dengan nyeri menstruasi adalah Indeks Massa Tubuh (IMT). Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dan nyeri...

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