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Beyond Paralinguistic Responsiveness: How Does a Pre-schooler Address His Gestural Communication?
This study ethnographically portrays the pre-schooler's gestures responsiveness with his existing autism spectrum disorder (ASD) and speech delay. This ethnographic study naturally accomplished the insightful qualitative analysis and interpretation observation and videotape recordings to address Levi's daily communication that became a single case study. Levi's paralinguistic...
Identifying and evaluating key excipients in commercial oral H1 antihistamine syrup formulations: A descriptive study of formulation approaches and selected safety concerns
Excipients are inactive substances required for the preparation of pharmaceutical forms. The efficacy, safety, and quality of syrup formulations depend on their composition, including excipients. Oral H1 antihistamine syrup formulations are most commonly used for pediatric and geriatric populations. Forty-one oral H1 antihistamine syrup formulations were initially identified. Of...
Prevalence and Risk Factors for Cytomegalovirus Retinitis Among People Living with HIV in Sub-Saharan Africa in the Antiretroviral Therapy Era: A Systematic Review and Meta-Analysis
Cytomegalovirus retinitis has remained an alarming and potentially vision-threatening opportunistic disease in the population living with HIV, especially in cases of extreme immunosuppression. Although the introduction of antiretroviral therapy has led to a drastic decline in the number of cytomegalovirus retinitis cases reported in most parts of the world, the current...
Effect of ultrasonic activation duration on micro-CT density of Well-Root™ PT apical plugs
The density and adaptation of the apical plug material during endodontic treatment of immature teeth are critical for minimizing microleakage and ensuring dimensional stability. This study assessed how different condensation techniques affect the micro-CT-measured density of apical plugs created with Well-Root™ PT. Apical plugs (5 mm thick) were created in 48 identical 3D-printed...
Self-Management of Geriatric Syndromes–longitudinal data on medical and psychosocial factors in older patients
Older patients who are acutely ill are a vulnerable group who are often excluded from scientific research. Nevertheless, psychosocial and health-related changes pose a particular challenge for this group that must be understood as our society continues to age. Geriatric syndromes, which are disease-unspecific, may particularly affect disease management and well-being. This...
Advancing justicidin B delivery by cinnamyl-functionalized polymeric micelles
Justicidin B (JB) is a biologically active arylnaphthalene lignan with significant therapeutic potential. However, its clinical application is limited by poor solubility and stability. In this study, cinnamyl-functionalized polyglycidol–poly(ε-caprolactone) (PG–PCL) polymeric micelles are developed and evaluated as nanocarriers for JB delivery. Both modified and non-modified...
Spontaneous eye blink rate indicates increased attention during grooming in female Barbary macaques
Spontaneous eye blinking is a ubiquitous behavior in animals including humans necessary for lubricating the ocular surface and preventing dryness. Beyond this functional role, eye blinking also provides a window into an animal’s cognitive state and attention allocation. Here in a purely observational study, we investigated in 13 female Barbary macaques (Macaca sylvanus) the...
Immunomodulatory and ROS-mediated anti-MMP-2/MMP-9 effects of lysine ethyl ester betulinate
This study examined the anti-invasive, immunomodulatory, and redox-modulating properties of betulinic acid (BA) and its ionic liquid derivative, [LysOEt][BA]2, in breast cancer and immune cell models. MDA-MB-231 cells were treated with increasing concentrations of BA or [LysOEt][BA]2 to evaluate intracellular reactive oxygen species (ROS) generation and matrix metalloproteinase-2...
Urinary IL-1β and plasma IFN-γ levels reveal complementary immune mechanisms in endometriosis
Objectives: Endometriosis is a multifactorial inflammatory disorder characterized by the coexistence of localized inflammatory activation and systemic immune dysregulation. Single biomarkers are unlikely to capture this biological complexity, underscoring the need for integrated immune profiling across different biological compartments. This pilot study evaluated IL-1β and IFN-γ...
Antitumor efficacy of cobalt–zinc ferrite nanoparticles on MCF-7 cell line and Ehrlich ascites carcinoma bearing mice
Cobalt–zinc ferrite nanoparticles (Co1−xZnxFe2O4; x = 0, 0.35) were synthesized using a flash-combustion method and characterized by FTIR and SEM to evaluate their structural and surface properties. This study investigated the in vitro and in vivo antitumor efficacy of cobalt ferrite nanoparticles (CF NPs). In vitro, human breast cancer cells (MCF-7) were used to determine...
Anti-aging potential of the endophyte Paenibacillus nuruki in a Saccharomyces cerevisiae lifespan model
The aim of the present study was to evaluate the potential of Paenibacillus nuruki AASFL403 extract (PBE) to extend the lifespan of Saccharomyces cerevisiae (Sc). The chronological lifespan assay was performed on three Sc strains with different genetic characteristics. Continuous or acute (30 min) treatment with PBE was performed with concentrations in the range of 0.1–2 mg/mL...
ARTIFICIAL INTELLIGENCE IN EDUCATION: TRANSFORMING THE LEARNING EXPERIENCE
In the modern digital age, Artificial Intelligence (AI) has emerged as a transformative force across various sectors, and education is no exception. AI technologies are redefining teaching methodologies, personalizing the learning experience, automating assessments, and enabling real-time feedback. This article explores the multifaceted impact of AI on education, emphasizing how...
Depth of response to primary POMB/ACE chemotherapy predicts survival in poor prognosis germ-cell tumours
BackgroundMost chemotherapy regimens for poor-risk non-seminomatous germ cell tumours (PRGCT) deliver a fixed number of cycles; the role of variable treatment duration aiming for maximal response is unknown. Since the 1970s, we have utilised POMB/ACE chemotherapy for PRGCT, treating until marker normalisation. From mid-1990s, treatment was limited to 7 cycles. We describe...
Experimental assessment of intravenous lipid emulsion in the management of acute fentanyl poisoning
Fentanyl is a highly potent and lipophilic μ-opioid receptor agonist associated with severe neurorespiratory toxicity and a growing incidence of overdose. Although naloxone remains the standard antidote, its relatively short half-life and exclusively pharmacodynamic mechanism of action may limit its efficacy in intoxications involving highly lipophilic opioids. The aim of this...
Viscoelastic profiling of rare pediatric extracranial tumors using multifrequency MR elastography: a pilot study
Magnetic resonance elastography (MRE) is a noninvasive technique for assessing viscoelastic properties of soft biological tissues in vivo, with potential relevance for tumor evaluation. This exploratory study aimed to assess the feasibility of multifrequency MRE in pediatric extracranial solid tumors and to investigate potential associations between viscoelastic parameters and...