The long noncoding RNA lnc13 restrains inflammatory responses to maintain oral tolerance to gluten

Celiac disease (CeD) is an autoimmune disorder triggered by dietary gluten. While HLA-DQ2/8-mediated presentation of gliadin peptides is required for disease, the mechanisms that underlie the loss of oral tolerance to gluten remain incompletely understood. Long-noncoding RNAs (lncRNAs) have been increasingly recognized as regulators of immune function, yet their role in oral...

Sex-specific systemic and brain metabolic responses to a standardized ketogenic diet in mice

Ketogenic diets (KDs) are widely used in preclinical research to investigate metabolism and neurological function, yet many studies lack methodological consistency and frequently exclude female animals. Here we investigated sex-specific systemic and brain metabolic responses to a standardized KD in mice, highlighting the need to include both sexes. Using the widely used C57BL/6J...

IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma

Allergic asthma is driven by type 2 immune responses, including type 2 innate lymphoid cells (ILC2s). Although ILC2s are activated by the tissue alarmins interleukin (IL)-33 and IL-25, these signals do not intrinsically enforce type 2 identity and the mechanisms that maintain type 2 cytokine expression remain unclear. Here we show that allergen-induced IL-33 and IL-25 rapidly...

Publisher Correction: Unlocking chemical diversity in aptamers with DNA orthogonal barcodes

Alternative antibiotic regimens improve palatability and welfare in mice for gut bacterial depletion

Here we evaluated vancomycin–neomycin or enrofloxacin–ampicillin treatments as alternatives to the poorly tolerated ampicillin–metronidazole–vancomycin–neomycin cocktail for gut bacterial depletion in mice. Both regimens were well tolerated in drinking water and did not reduce food intake or body weight. Metabolic profiling showed reduced bacterial metabolic activity in both...

Author Correction: Chemokine-defined macrophage niches establish spatial organization of tumor immunity

BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition

Germinal center B cell responses are defined by many positive regulators of affinity maturation, but few components that restrain clonal dominance, notably Nr4a1, are known. We reveal an unsuspected role for BLIMP1 (Prdm1)—a plasma cell determinant—as a feedback regulator of affinity maturation. Single-cell RNA and B cell receptor (BCR) sequencing showed that B cell-specific...

Moving beyond oral gavage: micropipette-guided drug administration (MDA) as a 3R refinement for voluntary oral drug delivery in rodents

Immunopeptidome profiling in pulmonary fibrosis provides a platform for identifying therapeutic targets

Fibrosis is a severe pathological outcome of many chronic diseases, yet the therapeutic potential of targeting the altered major histocompatibility complex (MHC) class I immunopeptidome remains largely unexplored. Here we characterized the MHC class I immunopeptidomes from both fibrotic foci of human idiopathic pulmonary fibrosis lung explants and bleomycin-treated mice...

Transforming our future by unlocking the power of DNA: the representation of health-related genomic testing in UK news items

Many people will have had no formal education on health-related genomic testing, so information from media sources may constitute a major influence in shaping ideas and expectations around genomic tests. We undertook a framing analysis of 186 UK news items discussing health-related genomic testing in the context of various recent UK-based initiatives: the 100,000 Genomes Project...

Modeling of complex physical and biological problems using bi-univalent function calculus

In recent years, bi-univalent functions and fractional calculus have attracted considerable attention due to their strong theoretical foundations and potential applications in applied sciences. However, most existing studies focus primarily on coefficient estimates from a purely theoretical perspective, with limited attention given to practical physical or biological...

Oxygen stoichiometry-driven charge compensation and Ruddlesden–Popper defects in ferromagnetic high-entropy manganite thin films

High-entropy oxides (HEOs) originate from an innovative materials design strategy that stabilizes single-phase solid solutions despite the inclusion of multiple principal elements into a single cation sublattice. While prior efforts have largely focused on cation disorder, the impact of anion defects on the structure and properties of HEOs remains unexplored. Here, we examine the...

Rhodoliths can act as daily resolution paleotemperature archives in the Red Sea

Long-term, high-frequency temperature records are critical for evaluating the vulnerability of marine ecosystems to ongoing ocean warming. Commonly used paleoceanographic archives, such as corals and bivalves, face regional and ecological constraints. Rhodoliths, free-living coralline red algal nodules, are established and globally accessible alternatives, yet their complex three...

Smartphone movement data can reliably predict smoking lapses and cravings to enable timely smoking cessation support

Decades of research aiming to develop effective smoking interventions have identified triggers that contribute to failed quitting attempts including environmental (e.g. location), social (presence of other smokers), or internal (e.g. stress). Here, it is shown for the first time that passively collected movement data from smokers’ smartphones’ sensors (accelerometer, gyroscope...

Konstruksi Brand Identity Produk Lokal: Studi Strategi Komunikasi Pemasaran Pemerintah Negeri Morella

Marketing communication strategy is an important element in business development, particularly in addressing the challenges of marketing local products. This study aims to examine the marketing communication strategies implemented by the Morella Village Government and Village-Owned Enterprises (BUMDES) in improving the marketing of Morella nutmeg juice products produced by local...

PEDAGOGICAL AND PSYCHOLOGICAL APPROACHES TO THE DEVELOPMENT OF SELF-ESTEEM IN PRESCHOOL CHILDREN

This article provides a theoretical analysis of pedagogical and psychological approaches to the development of self-esteem in children attending preschool educational institutions. The psychological essence of the concept of self-esteem, its role in the personal development of preschool children, and its relationship with social adaptation and future educational success are...

Sustainable high-throughput microwell spectrophotometric methods for avapritinib quality control via charge-transfer complexation

Avapritinib (AVA) is a breakthrough targeted therapy as the first potent inhibitor approved for gastrointestinal stromal tumors (GIST) with PDGFRA D842V mutations. It lacks convenient analytical methods for routine quality control. This study addresses this gap by developing and validating two novel, green, high-throughput microwell spectrophotometric methods (MW-SPMs) for AVA...

Author Correction: Biophysical prediction of protein–peptide interactions and signaling networks using machine learning

Pengaruh Kepemimpinan Transformasional dan Motivasi Terhadap Kinerja Guru Melalui Employee Engagement pada SMP di Kecamatan Tarogong Kaler Kabupaten Garut

Penelitian ini bertujuan untuk menganalisis pengaruh kepemimpinan transformasional dan motivasi terhadap kinerja guru dengan employee engagement sebagai variabel mediasi. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei terhadap 76 responden. Teknik analisis data yang digunakan adalah Structural Equation Modeling berbasis Partial Least Square menggunakan...

Comparison of ventilation with second-generation supraglottic airway devices in a prospective randomized cadaver study

Second-generation supraglottic airway devices (SADs) are widely used alternatives to endotracheal intubation in both anesthesia and emergency airway management. The newly developed LT®evo represents a redesigned version of the established Laryngeal Tube Suction Disposable (LTS-D). This study compared the ventilatory performance of the LT®evo with endotracheal intubation and three...

Islamic Tolerance as an Ethics of Coexistence in Muḥammad ʿImārah’s Thought

Debates on Islamic tolerance continue to turn on the relation between doctrinal conviction, freedom of conscience, and public coexistence in plural societies. This article examines how Muḥammad ʿImārah’s Al-Samāḥah al-Islāmiyyah constructs Islamic tolerance as coexistence ethics. Using directed qualitative content analysis, the study analyzes textual units concerning Qur'anic non...

Neodymium magnetic field meets nanocatalysis: a sustainable route to novel azines and condensed heterocycles

A sustainable and effective approach for manufacturing heterocyclic compounds was established utilizing Fe₃O₄ nanoparticles in the presence of a neodymium static magnetic field (about 9000 G). Pyrimidine, benzimidazole, quinoxaline, and benzodiazepine derivatives were swiftly synthesized at ambient temperature with excellent efficiency; no reaction transpired in the absence of a...

Genotype influences antidepressant discontinuation in a pre-emptive pharmacogenetic testing population

We performed a retrospective cohort study to evaluate risk of antidepressant discontinuation as a function of CYP2C19 and CYP2D6 phenotype. Patients who participated in an elective genomic screening and had a diagnosis of depression or anxiety with a corresponding antidepressant were analyzed. This resulted in 5 808 patients comprising 8 571 antidepressant orders. Of the total...

Author Correction: Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice

Correction: The effects of music and virtual reality on pain and anxiety during central venous port implantation: a randomised clinical trial

APPLICATION OF REPRESENTATIVES OF THE APIACEAE FAMILY IN PHARMACEUTICS AND MEDICINE

This article highlights the significance of plants belonging to the Apiaceae family in pharmaceuticals and folk medicine. Members of the lily family contain essential oils, flavonoids, alkaloids, vitamins, and other biologically active substances, which are widely used in the treatment and prevention of various diseases. The article analyzes the chemical composition and medicinal...

The Effect Of K3 On Employee Productivity Through Company Commitment And Culture: Systematic Literature Review (SLR) With Bibliometrics

This study aims to systematically analyze the influence of Occupational Safety and Health (K3) on employee productivity through organizational commitment and company culture using the Systematic Literature Review (SLR) approach. K3 has a strategic role in creating a safe and healthy work environment, which not only contributes to reducing the number of occupational accidents and...

Architectural and geotechnical aspects affecting earthquake resilience for the antique Egyptian Khufu pyramid

The Great Pyramid of Khufu, completed during Egypt’s Old Kingdom (2600–2450 BCE), exhibits the architectural expertise of ancient Pharaonic Egypt. To understand the structural longevity and earthquake resilience of this iconic monument, we carried out a comprehensive ambient noise survey employing horizontal-to-vertical spectral ratio (HVSR) analysis at 37 measurement points...

Field in the frame: an aerial view of greening Svalbard

Crowded Housing and Urban Residence as Risk Factors for Under-Five Children’s Pneumonia in Indonesia: Analysis of SSGI 2024 Data

Pneumonia remains the leading cause of morbidity and mortality among under-five children in Indonesia, with cases tending to increase each year. This study aimed to examine the association between crowded housing, cooking fuel type, nutritional status, sex, and classification of residence with the incidence of under-five children in Indonesia. This study used a cross-sectional...