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Fatty acid channelling into triglycerides and oxylipins drives ferroptosis resistance during oncogenic BRAF-induced senescence

Oncogene-induced senescence (OIS), a cellular programme initiated by activation of oncogenic signalling, provides a barrier to transformation and is accompanied by major reprogramming of cellular metabolism. We show here that induction of OIS by BRAFV600E expression in human diploid fibroblasts led to global changes in the cellular lipidome, characterised by a strong increase in...

ANALISA PENGARUH PERMEABILITAS TANAH TERHADAP PERSYARATAN KONSTRUKSI EMBUNG

Reservoir ponds (embung) are important infrastructures for water resource conservation, particularly in areas with hilly topography. The Malahayati University area has relatively steep slopes, which require reservoir construction capable of minimizing the potential for leakage. One of the technical factors influencing reservoir safety is the permeability of the soil used as the...

Pengaruh Pengetahuan Perpajakan, Sanksi Pajak, Kualitas Pelayanan Fiskus Terhadap Kepatuhan Wajib Pajak Orang Pribadi Dengan Kesadaran Pajak Sebagai Variabel Moderasi

This study aims to analyze the effect of tax knowledge, tax sanctions, and the quality of tax officer services on individual taxpayer compliance, with tax awareness as a moderating variable. The research was conducted at KPP Pratama Medan Timur. The population consisted of 130,468 individual taxpayers, with a sample of 400 respondents determined using purposive sampling and the...

Pengaruh Motivasi Dan Lingkungan Kerja Terhadap Kinerja Karyawan PT. Sigma Inti Presisi Karawang

Penelitian ini bertujuan untuk menganalisis pengaruh motivasi kerja dan lingkungan kerja terhadap kinerja karyawan PT. Sigma Inti Presisi Karawang. Metode penelitian yang digunakan adalah metode kuantitatif dengan pendekatan deskriftif dan verifikatif. Populasi penelitian terdiri dari seluruh karyawan PT. Sigma Inti Presisi Karawang sebanyak 54 orang, dengan teknik sampling jenuh...

The Relationship Between Breakfast Habits and Frequency of Snack Food Consumption with the Nutritional Status of Students at SMA Negeri 4 Surakarta

Adolescent nutritional status is influenced by multiple dietary behaviors, including breakfast habits and snack food consumption. This study aimed to examine the association between breakfast habits and snack consumption frequency with the nutritional status of students at SMA Negeri 4 Surakarta. An observational analytic study with a cross-sectional design was conducted among...

PENGARUH DAN DAMPAK LITERASI KEUANGAN TERHADAP PENGELOLAAN KEUANGAN UMKM STUDY KASUS PADA SHIS KEBAB

This study aims to analyze the role of financial literacy in shaping financial management behavior among Micro, Small, and Medium Enterprises (MSMEs). Financial literacy is an important aspect of business sustainability, as many MSME actors still operate their businesses without systematic financial management practices. This condition may affect the ability of business owners to...

Pengaruh Pajak Daerah, Retribusi Daerah dan PDRB Terhadap PAD Kota Medan

This study is motivated by the importance of Regional Original Revenue (PAD) as an indicator of regional financial independence influenced by local taxes, regional levies, and Gross Regional Domestic Product (GRDP). This study aims to analyze the effect of local taxes, regional levies, and GRDP on PAD in Medan City, both partially and simultaneously. This research uses a...

General workflow for localizing hydrides in metal nanoclusters by combining stochastic surface walking with neural-network potentials

Ligand-protected metal hydride nanoclusters are crucial for applications in catalysis, luminescence, and energy technologies. However, accurately locating hydrogen atoms (hydrides) within these complex structures remains a significant challenge, hindering the full exploitation of their properties. Developing a universal and accessible method for hydride localization is essential...

Analisis Disiplin Kerja Dalam Meningkatkan Kinerja Karyawan Pada PT Tri Jaya Teknik Karawang

Penelitian ini dilakukan untuk mengkaji tingkat disiplin kerja dalam meningkatkan kinerja karyawan pada PT Tri Jaya Teknik Karawang. Disiplin kerja memegang peranan krusial dalam mendukung produktivitas serta kelancaran proses produksi perusahaan. Penelitian ini mengunakan metode deskriptif dengan pendekatan kualitatif. Data diperoleh dengan melakukan wawancara dengan pihak HRD...

PERKEMBANGAN SASTRA JAHILIYAH DALAM MASYARAKAT ARAB PRA-ISLAM SEBAGAI CERMINAN BUDAYA, NILAI, DAN TRADISI SOSIAL HISTORIS

The development of Arabic literature during the Jahiliyyah period represents an important phenomenon reflecting the cultural dynamics, values, and social structure of pre-Islamic Arab society. This study aims to analyze the characteristics, social functions, and historical roles of Jahiliyyah literature in shaping the collective identity of Arab communities. This research employs...

Peran Literasi Investasi Dalam Meningkatkan Minat Masyarakat Terhadap Pasar Saham

Pasar saham merupakan salah satu instrumen investasi yang menjanjikan, namun partisipasi masyarakat di Indonesia masih relatif rendah dibandingkan negara-negara lain. Salah satu faktor utama yang berkontribusi terhadap rendahnya minat ini adalah kurangnya literasi investasi. Penelitian ini bertujuan untuk menganalisis secara komprehensif peran literasi investasi dalam...

Keputusan Penggunaan QRIS Berdasarkan Pengaruh Persepsi Kemudahan dan Keamanan Melalui Persepsi Kepercayaan Pada GEN_Z di Tawangmangu

This study was conducted to analyze the impact of perceived ease of use and perceived security on the decision to use QRIS, with perceived trust as a mediating variable. The sample was taken using a purposive approach with the size determined using the hair formula. This study was conducted in Tawangmangu District using a quantitative approach and survey method. The questionnaire...

Emulation of coherent absorption of Fock-state quantum light in a programmable linear photonic circuit

Non-Hermitian quantum systems, governed by nonunitary evolution, offer powerful tools for manipulating quantum states through engineered loss. A prime example is coherent absorption, where quantum states undergo phase-dependent partial or complete absorption in a lossy medium. Here, we demonstrate a fully programmable implementation of nonunitary transformations that emulate...

INTEGRASI ARTIFICIAL INTELLIGENCE DAN ESG DALAM SISTEM EKONOMI MODERN

The rapid development of Artificial Intelligence (AI) has driven significant transformations in accounting systems, particularly in supporting sustainability reporting based on Environmental, Social, and Governance (ESG) principles. However, comprehensive studies that examine the integration of AI and ESG within the context of modern accounting systems remain relatively limited...

Pengaruh Motivasi Kerja Dan Lingkungan Kerja Terhadap Kinerja Perawat Pada RS Dewi Sri Karawang

Penelitian ini bertujuan untuk menganalisis pengaruh motivasi kerja dan lingkungan kerja terhadap kinerja perawat di Rumah Sakit Dewi Sri Karawang. Metode yang digunakan adalah kuantitatif dengan pendekatan deskriptif verifikatif. Populasi berjumlah 138 karawang, dengan sampel terdiri dari 103 responden yang ditentukan dengan rumus Slovin. Data dikumpulkan melalui kuesioner dan...

Freeform optical flow based on meta-conveyors for compact, programmable in situ nanomanipulation

Programming light flow offers significant potential for diverse applications. However, conventional spatial light modulators are bulky, have large pixels, and slow switching. Miniaturized metasurface strategies offer flexibility but are limited to radial or azimuthal phase gradients, hindering free shaping of light flow in ultracompact footprints. Here, we present a meta-conveyor...

Perbandingan Algoritma Machine Learning dalam Klasifikasi Serangan Phishing pada E-mail

Serangan phishing melalui email merupakan ancaman siber yang terus meningkat dan berpotensi menyebabkan kebocoran data sensitif. Penelitian ini bertujuan membandingkan kinerja tiga algoritma Machine Learning, yaitu Gradient Boosting, Random Forest, dan Logistic Regression dalam mengklasifikasikan email phishing dan non-phishing. Dataset diproses melalui tahapan pembersihan teks...

AUDIT SYARIAH SEBAGAI INSTRUMEN PENCEGAHAN MORAL HAZARD DALAM PEMBIAYAAN SYARIAH

The rapid growth of Islamic financial institutions requires the presence of an effective supervisory system to ensure compliance with Sharia principles while minimizing the potential for moral hazard in financing activities. Moral hazard problems generally arise due to information asymmetry between financial institutions and customers, as well as weak control mechanisms over the...

Trees halve urban heat island effect globally but unequal benefits only modestly mitigate climate-change warming

Although tree cover reduces the urban heat island, no global estimate quantifies air temperature reductions by contemporary or future tree cover, currently and with climate change. Here, we estimate these reductions for all 8,919 large urban areas. Current urban tree cover mitigates 41–49% of the maximum potential air-temperature urban heat island that would occur in the absence...

Pengaruh Struktur Modal dan Profitabilitas Terhadap Harga Saham Dengan Ukuran Perusahaan Sebagai Variabel Moderasi

This study aims to examine the effect of capital structure and profitability on stock prices, with firm size as a moderating variable, in energy sector companies listed on the Indonesia Stock Exchange (IDX) during the 2019–2023 period. The background of this research is based on the inconsistency of previous study results regarding the influence of capital structure and...

Role of Consumer Engagement in TikTok Content and Fashion Purchase Decisions among Gen Z Muslims

The emergence of digital marketing strategies centered around social media platforms, notably TikTok, has significantly transformed the purchasing behaviors of Generation Z consumers in the fashion sector. Nonetheless, the underlying psychological processes that connect the impact of digital content to purchasing decisions remain underexplored. This research endeavors to examine...

Eye movement kinematics reveal novel circadian organization of sleep substates

In most non-mammalian model organisms, sleep is operationally defined as persistent locomotor quiescence (e.g., ≥1 min) associated with decreased arousal1,2,3. In contrast to the long-established subdivision of mammalian sleep by eye movements4,5,6,7,8,9, the existence of sleep-associated eye movements and, more broadly, discrete sleep substates in non-mammalian organisms remains...

KEMANDIRIAN EKONOMI RUMAH TANGGA MELALUI AFFILIATE TIKTOK SHOPE DALAM PERSPEKTIF MAQASHID SYARIAH DI JEMBER

The development of the digital economy has led to the emergence of various platform-based income schemes, including the TikTok Shop affiliate program utilized by households. This phenomenon is important to examine as it relates not only to income generation but also to how such income is utilized to strengthen household economic independence. Previous studies have primarily...

Examining The Mediating Role of Negative Dyadic Coping between Parental Stress and Child Externalizing Behavior

Introduction: Behavioral problems have become a concern that often occurs in children, especially in elementary schools, and have not been appropriately handled. Behavioral problems that often occurs in children is externalizing behavior. One of the factors that can affect externalizing behavior is the character of parenting seen from parental stress. This research aims to know...

MechFind: a computational framework for de novo prediction of enzyme mechanisms

Fewer than one thousand cataloged mechanistic annotations can be found in the open literature and databases. Here, we introduce MechFind, a computational tool that generates element and charge-balanced putative enzyme mechanisms using only the reaction stoichiometry. Unlike methods requiring structural data, MechFind abstracts reaction steps as changes in chemical moieties. It...

Pengaruh Financial Technology dan Pemanfaatan Sistem Informasi Akuntansi Terhadap Kinerja Keuangan UMKM Kuliner di Foodcourt Medan Estate

This study aims to analyze the effect of financial technology (fintech) and the utilization of accounting information systems (AIS) on the financial performance of culinary MSMEs at Foodcourt Medan Estate, Deli Serdang Regency. The research background highlights the low adoption of digital technology among MSMEs, both in financial transactions and accounting records, which...

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