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Background Twenty-first century dentistry in first world countries should be based on sound evidence-based prevention and timely access to relevant dental care, but is not the picture currently portrayed of dentistry within the UK, by and for the key players involved (e.g., patients/public, government/commissioners, National Health Service, contract providers and performer...
Recurrent transitions in feeding strategies have shaped the eukaryotic tree of life, as unrelated groups independently evolved similar solutions to common ecological challenges. One of the most interesting yet poorly studied of these shifts is the transition towards osmotrophy. We reconstructed the evolution of four eukaryotic groups that specialized in osmotrophy through...
Tropical rainforests have often been considered marginal environments for Pleistocene hunter-gatherers, yet archaeological research in Sri Lanka demonstrates long-term occupation of these habitats from ~48,000 years ago (ka). Material evidence indicates specialized hunting of arboreal mammals, as well as the use of plant resources, but plant consumption is often difficult to...
Achieving global biodiversity targets, such as the commitment to conserve 30% of the planet by 2030, depends on the ability of individual countries to translate targets into reality. While there has long been recognition that protected areas can bring costs as well as benefits, the implications of this for delivery of global targets have not been fully explored. We focus on...
Aims Describes the development and early implementation of the Cancer Action Support Practice (CASP) pathway in South West England, aiming to improve dental care access for head and neck cancer (HNC) survivors in the primary care setting.Summary of CASP development Stakeholder engagement was central to CASP's design, involving input from general dental practitioners, local dental...
Yellow-eyed penguins (hoiho/takaraka, Megadyptes antipodes) are among the world’s rarest penguins and considered taonga (treasured) species in Aotearoa New Zealand. Since 2019, chicks on the New Zealand mainland have been affected by a deadly neonatal disease, respiratory distress syndrome, contributing to a decline to fewer than 115 breeding pairs. To investigate the putative...
This research is motivated by the fact that the professionalism of elementary school teachers' performance is still not optimal. The purpose of this research is the influence of coaching-based supervision and motivation on the professionalism of teacher performance. The quantitative inferential approach with the survey method Multiple linear regression Population of 100 teachers...
Accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy is among the strongest signatures of ageing1. Here we investigated the underlying mechanism by calling mtDNA sequence, mtDNA abundance and mtDNA heteroplasmic variants in human blood using whole-genome sequences from approximately 750,000 individuals. We observed that mtDNA single-nucleotide variants (mtSNVs...
In this study, we investigate the stochastic nonlinear Schrödinger equation incorporating self-phase modulation under the influence of multiplicative white noise in the dispersionless regime. By employing the improved modified extended tanh function method , we derive a rich spectrum of analytical solutions, including bright and dark solitons, singular and periodic structures, as...
Hypertension and organ damage caused by an inappropriate balance between aldosterone and salt are deeply involved in pathologies such as chronic heart failure, chronic kidney disease, and vascular disorders. Mineralocorticoid receptor antagonists are effective not only as antihypertensives, but also as organ-protective drugs, blocking direct aldosterone-induced organ damage...
Before each of around 200,000 eye movements we make each day, the brain decides how long to fixate before shifting gaze to new information. Here we investigate this process using a large-scale scene-viewing experiment (4,080 natural scenes, five participants) that combines magnetoencephalography, eye tracking and a semantic captioning task. Using multivariate analysis of...