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HIF-1α integrates lipogenic FASN and glycolytic GLUT3 to overcome intratumor oxidative and hypoxic stress for colorectal cancer metastasis
Colorectal carcinoma (CRC) remains a leading cause of cancer mortality, largely due to metastasis. Solid tumors, including CRC, must adapt to intratumoral hypoxia and oxidative stress, but the tumor-cell programs that couple these pressures to metastatic competence remain unclear. Across human CRC cohorts and cell lines, HIF-1α was coordinately upregulated and co-expressed with...
The Differences in the Effects of Single Leg Hopping and TherabandExercise on Dynamic Balance in Soccer Players with Chronic AnkleInstability
Background: Chronic Ankle Instability (CAI) occurs in soccer players who have experienced ankle sprains without receiving appropriate physiotherapy intervention. This condition can lead to decreased proprioceptive response, increased ligament weakness, and reduced muscle strength, ultimately affecting dynamic balance. Interventions that can be applied in this condition include...
The Effect of Proprioceptive Training on Knee Joint Stability in Anterior Cruciate Ligament Injuries
Anterior Cruciate Ligament (ACL) injury is a disorder of the knee joint that often causes instability and decreased movement function. In addition to structural damage, this injury also impacts the decline in proprioception, which plays a role in neuromuscular control. This decline can disrupt balance and coordination of movement, thereby increasing the risk of recurrent injury...
Pengaruh Tingkat Protein Kasar terhadap Stabilitas Kualitas Fisik Telur ISA Brown Fase Late Laying: Effect of Dietary Crude Protein Level on the Stability of Physical Egg Quality of ISA Brown During the Late Laying Phase
The extension of laying hens’ productive lifespan up to 100 weeks is associated with a decline in egg physical quality during the late laying phase due to reduced magnum gland function and impaired liver health, leading to albumen thinning and weakening of the vitelline membrane, which may result in failure to meet SNI 3926:2023 standards. This study aimed to determine the...
The Effect of Early Mobilization on Pain Intensity in Post-Cesarean Section (CS) Patients in Ward 2B at Grandmed Hospital Lubuk Pakam
Cesarean section is a commonly performed delivery procedure that may cause postoperative pain due to tissue incision. Inadequately managed pain can delay the patient’s recovery process. One of the non-pharmacological interventions that can be applied to reduce pain is early mobilization. This study aimed to determine the effect of early mobilization on pain intensity among post...
The Effectiveness of Herbal Plant Extracts in Burn Wound Care: A Systematic Literature Review
Background: Burns are tissue injuries caused by various thermal, chemical, or electrical agents, resulting in serious skin damage that requires comprehensive management. Traditional burn care often utilizes herbal plants due to their bioactive compounds, which have the potential to accelerate the healing process and reduce complications. Objective: This study aims to...
Pengaruh Level Penggunaan Sorghum bicolor-Indigofera zollingeriana yang Difermentasi (Sorinfer) terhadap Performa Domba Pejantan: Effect of Fermented Sorghum bicolor-Indigofera zollingeriana (Sorinfer) Inclusion Level on the Growth Performance of Rams
This study aimed to evaluate the effect of fermented Sorghum bicolor-Indigofera zollingeriana (Sorinfer) silage at distinct levels on the performance of local rams. Studies were conducted over 7 weeks using 20 rams, with an initial body weight of 20,90±3,72 kg. Rams were divided into 5 treatments with 4 replicates, consisting of 100% field grass (P0), 75% P0 + 25% Sorinfer (P1...
MST4 plays dual roles in lung adenocarcinoma by regulating homeostasis of wild-type and mutant p53 protein
Mutations are highly prevalent in the TP53 tumor suppressor gene, which encodes p53, in lung adenocarcinoma (LUAD). However, targeted therapies centered on p53 mutations remain challenging. Here, we found MST4 highly expressed in LUAD and linked to patient survival. Functional assays using CRISPR-generated MST4-knockout LUAD cell lines revealed context-dependent dual roles of...
The Effect of Using a Neck Roll Pillow with a Sniffing Position on Oxygen Saturation in Post Operative Patients under General Anesthesia
Postoperative patients undergoing general anesthesia are at risk of decreased oxygen saturation during the early recovery phase due to reduced consciousness, muscle relaxation, and upper airway obstruction. This condition requires appropriate airway management to maintain airway patency. One non-pharmacological intervention that can be applied is patient positioning in the...
Artificial Intelligence–Generated Deepfake Pornography: A Normative Analysis of Criminal Liability and Victim Protection in Indonesian Law
The rapid development of artificial intelligence (AI) has facilitated the creation of deepfake pornography through non-consensual digital manipulation of a person’s image, raising significant legal and human rights concerns. This study aims to examine the adequacy of Indonesian positive law in addressing AI-generated deepfake pornography, analyze the construction of criminal...
Different Effect Of Neck Stabilization Exercise With Stretching On Improving Neck Functional Ability In Non-Specific Neck Pain
Latar belakang: Pekerja kantoran dengan posisi menunduk dan statis dalam waktu yang lama, otot akan berkontraksi berlebih sehingga terjadi spasme dan nyeri menyebabkan nyeri leher non spesifik lalu akan mengganggu kemampuan fungsional leher. Neck stabilization exercise dan stretching dapat menjadi latihan untuk meningkatkan kemampuan fungsional leher pada nyeri leher non spesifik...
The Effect Of Senior Exercise In A Sitting Position Using Cloth On Cardiovascular Load
Introduction: The aging process causes a decline in physiological functions, including the cardiovascular system, which increases the risk of hypertension and heart disease in the elderly. Physical activities like elderly gymnastics have been shown to maintain fitness and reduce the risk of these diseases. However, mobility limitations and concerns about injury make it difficult...
Potensi Hijauan Pakan Perkebunan Kelapa Sawit untuk Pengembangan Sapi di Kecamatan Kaliorang Kabupaten Kutai Timur: Study on the Potential of Forage Resources in Oil Palm Plantations for Cattle Development in Kaliorang, East Kutai Regency
This study aims to examine the potential of forage crops in oil palm plantations for cattle maintenance in Kaliorang District, East Kutai Regency. The research method uses an exploratory survey with a quantitative descriptive approach, using a 1 m² plot sampling technique. The design employed is a Randomized Complete Block Design (RCBD) with 3 treatments based on oil palm age (3...
Implementation of Online Patient Reservation Registration at Hospital
The development of information technology has encouraged digital transformation in healthcare services, including patient registration systems in hospitals. The implementation of online registration systems aims to improve service efficiency, reduce patient waiting times, and facilitate public access to healthcare services. Grandmed Hospital Lubuk Pakam has implemented an online...
The Influence Of Balloon Blowing Practice On Respiration Rate And Oxygen Saturation In Asthma Patients In Grandmed Hospital Lubuk Pakam
The illness known as asthma is typified by persistent inflammation of the airways involving various types of mediators and inflammatory cells that are interrelated and cause changes in the shape and structure of the airways. One method of treating asthma is balloon blowing therapy. The aims of this study was to examine the effect of ballon blowing therapy on respiratory rete and...
An ex vivo permissivity assay to assess replication of the oncolytic virus VSV-GP in patient-derived tumor samples
The sparking interest in oncolytic viruses (OV) faces challenges in clinical translation due to limitations of pre-clinical models and the lack of predictive biomarkers for OV activity. Furthermore, functional assays which could determine permissivity of human tumors to OVs in a straightforward way are still lacking. Here, we present a novel ex vivo permissivity assay to...
Respons Parameter Eritrogram Sapi Perah Peranakan Friesian Holstein Laktasi terhadap Suplementasi Daun Lamtoro (Leucaena leucocephala): Response of Lactating Friesian Holstein Crossbred Dairy Cows Erythrogram Parameters to Lamtoro Leaf (Leucaena leucocephala) Supplementation
Optimizing the physiological status of lactating dairy cows is greatly influenced by feed quality, particularly the availability of adequate protein and minerals to support systemic functions. This study was conducted to evaluate the erythrocyte response of lactating Peranakan Friesian Holstein (PFH) dairy cows supplemented with lamtoro leaves (Leucaena leucocephala). Twelve...
The Effectiveness of PC6 Self-Acupressure on Nausea and Vomoting in Cancer Patients Undergoing Chemotherapy at Grandmed Hospital Lubuk Pakam
Background: Chemotherapy-induced nausea and vomiting are among the most common side effects experienced by cancer patients and significantly affect their quality of life. This study aimed to analyze the effectiveness of self-acupressure at the PC6 point in reducing the severity of nausea and vomiting among patients undergoing chemotherapy at Grandmed Hospital Lubuk Pakam. A...
The Effect of Husband Support During Labor on the Duration of the First Stage of Labor and Anxiety Levels Among Primigravida Mothers at Clinic X
Background: Childbirth is a physiological process that often leads to anxiety, particularly among primigravida mothers who have no prior experience with labor. Elevated anxiety levels may influence uterine contractions and potentially prolong the duration of the first stage of labor. One non-pharmacological approach to reducing maternal anxiety is emotional support from the...
The Effect of Giving Cinnamon Infusion with Honey on Primary Dysmenorrhea Pain in Adolescents
Primary dysmenorrhea is a condition that may reduce adolescents’ quality of life, as it can interfere with daily activities and increase the risk of absenteeism from school or work. The management of this condition remains suboptimal, as most adolescents tend to rely on analgesic medications, while the long-term use of chemical drugs is associated with potential adverse effects...
Persentase Karkas, Potongan Komersial, dan Rasio Daging Tulang pada Ayam IPB-D3 yang Disuplementasi Vitamin E dalam Pakan: Carcass Percentage, Commercial Cuts, and Meat-to-Bone Ratio in IPB-D3 Chickens Supplemented with Vitamin E in the Diet
Vitamin E plays an important role in poultry nutrition as a potent antioxidant, supports immune function, and contributes to improved carcass quality in chickens. This study aimed to evaluate the effect of vitamin E supplementation combined with increased dietary nutrient levels on carcass characteristics, non-carcass components, and the meat-to-bone ratio of IPB-D3 chickens. A...
Gluteus Muscle Activation Training On Myogenic Low Back Pain: A Case Report
Myogenic low back pain is one of the musculoskeletal disorders caused by dysfunction of muscles and supporting soft tissues such as tendons and ligaments. This condition is often associated with repetitive activities, excessive muscle use, and poor postural habits during daily activities. Myogenic low back pain can lead to reduced functional capacity and decreased productivity...
Lactic acid induces dendritic cell pyroptosis through MCT-1 to promote tumor immune evasion
Elevated metabolites in the tumor microenvironment (TME), particularly lactic acid, create an immunosuppressive milieu that promotes immune escape and tumor progression. Dendritic cells (DCs) are pivotal in initiating and regulating immune responses against tumors. However, the impact of lactic acid on DC death in the TME remains unclear. Our study reveals that lactic acid...
113Mothers' Knowledge and Attitudes in the First 1,000 Days of Life (HPK) Regarding Stunting Prevention Behaviors
Stunting is a public health problem caused by chronic malnutrition, particularly during the first 1,000 days of life (HPK). Maternal factors such as knowledge, attitudes, and behavior play a crucial role in stunting prevention efforts through appropriate feeding practices and utilization of health services. This quantitative research design employed a descriptive correlational...
Evaluasi Kualitas Spermatozoa Kambing Boer Dengan Penambahan Ekstrak Bunga Telang (Clitoria ternatea) Dalam Pengencer Skim Kuning Telur: Evaluation of Boer Goat Spermatozoa Quality with the Addition of Butterfly Pea Flower Extract in Skim Milk Egg Yolk Extender
This study aims to evaluate the addition of butterfly pea flower extract as a natural antioxidant source in Skim Milk with Egg Yolk on the quality of Boer goat spermatozoa. The study used a Randomized Block Design (RBD) with five treatments and four replicates, and the data were further analyzed using Duncan's test. The treatments consisted of sperm added to skim milk (control...
The Effect of Red Ginger Decoction Administration on the Reduction of Dysmenorrhea Pain among Female Adolescents at Nusantara Private Senior High School, Lubuk Pakam
Menstruation in adolescents is one of the indicators of biological maturity that occurs during puberty and signifies a woman’s readiness for pregnancy. Women’s reproductive health is influenced by various factors, including nutritional status and body weight. In addition, women often experience various menstrual-related problems, one of which is menstrual pain or dysmenorrhea...
Effectiveness Of Family-Centered Care-Based Supportive Educative Nursing Intervention (SENI) On Increasing Progressive Muscle Mobilization In Stroke Patients At Sembiring Deli Tua General Hospital In 2026
Stroke is a leading cause of disability and often results in motor function impairment, particularly a decrease in muscle mobilization ability. Stroke patient rehabilitation requires structured nursing interventions and active family involvement. Supportive Educative Nursing Intervention (SENI) based on Family-Centered Care is a nursing approach that emphasizes education, support...
Komposisi Kimia Daging Kalkun Lokal yang Diberi Berbagai Hijauan sebagai Bahan Pakan: Chemical Composition of Local Turkey Meat Given Various Green Fodders as Feed Ingredients
The objective of this study was to evaluate the inclusion of Eichhornia crassipes, Indigofera sp., and Ipomea spp. in the ration on chemical composition and meat-to-bone ratio of the breast and thigh of turkey. A total of 12 male turkeys at 42 weeks of age with an average weight of 5097±163.88 g were used in this study. The rations were formulated using 38% rice bran, 35...
Relationship Between Cognitive Function And Resilience Levels In The Elderly
The elderly are a group that is vulnerable to cognitive decline due to the aging process, which can affect their psychological adaptation and resilience in facing physical, social, and emotional changes. Resilience is an important factor in maintaining the quality of life of the elderly, so the relationship between cognitive function and resilience levels needs to be further...
Closed kinetic chain (CKC) Exercise In Knee Joint Rehabilitation: A Narrative Review
Musculoskeletal disorders of the knee joint are common health problems that can cause pain, decreased physical function, and limitations in daily activities. This study aimed to synthesize scientific evidence on the effectiveness of closed kinetic chain exercises on pain, physical function, balance, and mobility in musculoskeletal disorders, particularly in the knee joint. This...